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Coenzyme Q10 production base was completed and put into production in May 2019
In the early 1980s, Japan realized the synthesis of coenzyme Q10 by extracting solanesol from tobacco leaves, which greatly reduced the cost of coenzyme Q10, which played an important role in promoting the application, popularization and promotion of coenzyme Q10. The semi-chemical synthesis method is technically mature and has been industrialized. The product cost is low and the price is moderate. However, although the products produced by the semi-chemical synthesis method have advantages in price, there is a big gap in the use compared with the products produced by the biological extraction method. The reason is that the biological extraction method produces natural and organic products, which are easily absorbed and transformed by the human body, while the chemical synthesis method produces artificial chemically synthesized organic products, which have extremely poor biological activity and are not easily absorbed by the human body, and it is difficult to give full play to Coenzyme Q10. Pharmacological effects. The chemical synthesis method of coenzyme Q10 has always been a hot research topic at home and abroad. In the past half century, developed countries have realized the production of coenzyme Q10 by microbial fermentation in 1977. In recent years, the microbial fermentation extraction method has made considerable progress. The new bioengineering method not only integrates the advantages of the biological extraction process and the chemical synthesis process, but also overcomes their shortcomings. Therefore, it is the most eye-catching and promising method for industrialization.
There are two main requirements for the microbial fermentation extraction method to achieve industrial production:
(1) A high-quality coenzyme Q10 transgenic strain that requires a stable large-scale production process;
(2) The technology of high-precision separation instrument is required. Japan is the earliest and most important coenzyme Q10 producer in the world. According to statistics, 90% of the world's coenzyme Q10 comes from Japan. The two Japanese companies with the highest output of coenzyme Q10 are "Nissin Flour Mills" and "Kyowa Fermentation Co., Ltd.".
The research and exploration of countless experts are mainly carried out from two aspects: one is to introduce decaprenol group (decaprenol) on the core compound, and the other method is to first introduce a shorter compound on the core compound. And then introduce the desired long chain.
In 1959, R. Ruegg et al. reported the synthesis of coenzyme Q10 using the route shown in formula (1). Although the product is obtained, the yield is only 20%, and because the allylation reagent prepared by solanesol is a mixture of cis and trans isomers and needs to be separated, the application of this method is limited.